Dr Roben Gieling PhD
Research Associate
- Email: roben.gieling@manchester.ac.uk
- Telephone: +44 (0)161 275 7004
University of Manchester
Stopford Building, Oxford Road
School of Pharmacy and Pharmaceutical Sciences
Hypoxia and Therapeutics Group Room 3.128
M13 9PT Manchester
Role
Biomedical research in the context of tumour biology with special attention to:
- The inflammatory response associated with tumour development.
- NFkappaB signalling in tumour development.
- The use of the hypoxic environment in solid tumours in therapy.
- Hypoxia -> HIF-1alpha -> VEGF (angiogenesis) signalling pathway
Memberships of Committees and Professional Bodies
Member of the British Association of the Liver (BASL)
Member of the British Association for Cancer Research (BACR)
Registered with the Health Professions Council (HPC) Reg No. BS63318
Research
Studying the inflammatory and extracellular matrix components in liver fibrosis and hepatocellular carcinoma (molecular pathology). Expanded to other models as the xenograft transplantation models of cancer.
Recently successful completed a level 5 Award certified by the leading European awarding body ILM (Institute of Leadership and Management) for Researchers into Management in the UoM.
Methodological Knowledge
Immunohistochemistry (IHC, IF), Western Blotting, Real-time PCR (Taqman, Sybr Green)
Elisa, etc
Biography
1992-1997 Under Graduate Medical Biology Faculty of Medicine University of Utrecht (The Netherlands)
1997-1998 Research Assistent Dept of Neurology RWTH Aachen (Germany)
1998-2005 Post Graduate Researcher Hepatology AMC University of Amsterdam (The Netherlands)
2003-2004 Assessor Toxicology CTB Wageningen (The Netherlands)
2005-2007 Post Doc Dept of Surgery USC Los Angeles (United States)
2007-2010 Post Doc Cell Signalling Group University of Newcastle upon Tyne
2010-present Post Doc Hypoxia and Therapeutics Group University of Manchester
Qualifications
2005 PhD degree from the University of Amsterdam (The Netherlands)
1997 Masters degree in Medical Biology from the University of Utrecht (The Netherlands)
Collaborators and affiliated staff
Affiliated Staff: Dr Kaye Williams - Group Leader - Hypoxia and Therapeutics Group
Collaborators:
Professor Derek A Mann - nuclear factor kappa b (NF-kB) signalling - Newcastle University
Dr Richard Fitzmaurice - Consultant Histopathologist - Central Manchester University Hospitals NHS Foundation Trust
Publications
2010
- Gieling RG, Elsharkawy AM, Caamano JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA. (2010). The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferation. Hepatology, 51(3), 922-931. eScholarID:78615 | DOI:10.1002/hep.23385
2009
- Gieling RG, Wallace K, Han YP. (2009). Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol, 296(6), G1324-G1331. eScholarID:78617 | DOI:10.1152/ajpgi.90564.2008
- Zhou L, Yan C, Gieling RG, Kida Y, Garner W, Li W, Han YP. (2009). Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. BMC Immunol, 10, 15. eScholarID:78618
2008
- Gieling RG, Burt AD, Mann DA. (2008). Fibrosis and cirrhosis reversibility - molecular mechanisms. Clin Liver Dis, 12(4), 915-937. eScholarID:78619 | DOI:10.1016/j.cld.2008.07.001
- Watson MR, Wallace K, Gieling RG, Manas DM, Jaffray E, Hay RT, Mann DA, Oakley F. (2008). NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts. J Hepatol, 48(4), 589-597. eScholarID:78620 | DOI:10.1016/j.jhep.2007.12.019
2005
- R.G. Gieling. (2005). Changes in blood flow that affect hepatic gene expression. University of Amsterdam Faculty of Medicine. eScholarID:78699
2004
- Gieling RG, Ruijter JM, Maas AA, Van Den Bergh Weerman MA, Dingemans KP, ten Kate FJ, Lekanne dit Deprez RH, Moorman AF, Lamers WH. (2004). Hepatic response to right ventricular pressure overload. Gastroenterology, 127(4), 1210-1221. eScholarID:78622
- Ruijter JM, Gieling RG, Markman MM, Hagoort J, Lamers WH. (2004). Stereological measurement of porto-central gradients in gene expression in mouse liver. Hepatology, 39(2), 343-352. eScholarID:78626
2000
- Brook GA, Houweling DA, Gieling RG, Hermanns T, Joosten EA, Bar DP, Gispen WH, Schmitt AB, Leprince P, Noth J, Nacimiento W. (2000). Attempted endogenous tissue repair following experimental spinal cord injury in the rat: involvement of cell adhesion molecules L1 and NCAM? Eur J Neurosci, 12(9), 3224-3238. eScholarID:78627
1999
- Houweling DA, Brook GA, Gieling RG, Veldman H, Woodhams PL, Nacimiento W, Noth J, Bar PR, Joosten EA. (1999). Differential distribution of immunoreactivity in the developing rat spinal cord revealed by the monoclonal antibody Py. Brain Res Dev Brain Res, 116(1), 87-96. eScholarID:78628