Dr Costas Demonacos
Lecturer in Cancer Pharmacology
- Email: cdemonacos@manchester.ac.uk
- Telephone: +44 (0)161 275 1793
- Alternative Telephone: +44 (0)161 275 2487 (Group Secretary)
- Fax: 0161 275 2396
Memberships of Committees and Professional Bodies
Academic Pharmacy Group, Royal Pharmaceutical Society of Great Britain The European Association for Cancer Research
American Association for the Advancement of Science
New York Academy of Sciences Society for Endocrinology
The Biochemical Society
Marie Curie Fellows Association
Hellenic Biochemical Biophysical Society
Hellenic Association of Pharmaceutical Chemistry
Hellenic Association of Pharmacists
Research
Mechanisms of cell cycle regulation.
Novel biological networks involving transcriptional co-factors in the regulation of cell cycle and apoptosis.
Regulatory mechanisms controlling the malignant transformation through nuclear and mitochondrial inter-genomic signalling pathways.
Methodological Knowledge
Molecular Biology (regulation of gene expression)
Biochemistry (protein-protein interaction)
Molecular Pharmacology (dissection of molecular pathways with therapeutic targeting potential)
Teaching
Pharmaceutical Immunology
Cancer Biology and Therapy
Extemporaneous Formulations (Practical lecturer)
Biography
Costas graduated as pharmacist in 1983, from University of Thessaloniki, School of Pharmacy.
He was awarded PhD in 1994, in Molecular Biology and Biochemistry from University of Athens, School of Biology.
He has acquired experience in a wide spectrum of pharmaceutical sciences working as a community and hospital pharmacist as well as quality control scientist in pharmaceutical industry.
Collaborators and affiliated staff
- Dr Evangelia Charmandari, The Foundation for Biomedical Research of the Academy of Athens
- Dr Paraskevi Moutsatsou, Department of Biological Chemistry, Medical School, University of Athens
- Dr Michalis Alexis, National Hellenic Research Foundation, Institute for Biological Research and Biotechnology
- Dr Marija Krstic-Demonacos, University of Manchester, Faculty of Life Sciences
- Dr Alexander Golovanov, University of Manchester, Faculty of Life Sciences and Manchester Interdisciplinary Biocentre
- Dr Aris Dokoumetzidis, University of Athens, Pharmacokinetics and Biopharmaceutics
- Dr Triantafyllos Liloglou, University of Liverpool, School of Cancer
Selected publications
2010
- Lynch, J., Rajendran, R., Xenaki, G., Berrou, I., Demonacos, C. & Krstic-Demonacos, M (2010). The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Mol Cancer, 9, 38. eScholarID:81716 | PMID:20156337 | DOI:10.1186/1476-4598-9-38
2008
- Davies L, Karthikeyan N, Lynch J, Sial E, Gkourtsa A, Demonacos C, Krstic-Demonacos M. (2008). Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function. Mol Endocrinol, 22( 6), 1331-44. eScholarID:1d17358 | DOI:10.1210/me.2007-0360
- Xenaki G, Ontikatze T, Rajendran R, Stratford IJ, Dive C, Krstic-Demonacos M, Demonacos C. (2008). PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene, 27, 5785-5796. eScholarID:1d17620 | DOI:10.1038/onc.2008.192
2004
- Demonacos C, Krstic-Demonacos M, Smith L, Xu D, O'Connor DP, Jansson M, La Thangue NB. (2004). A new effector pathway links ATM kinase with the DNA damage response. Nature Cell Biology, 6(10), 968-976. eScholarID:1d8339 | DOI:10.1038/ncb1170
- Erler, J, Cawthorne, C, Williams, K, Koritzinsky, M, Wouters, B, Wilson, C, Miller, C, Demonacos, C, Stratford, I, Dive, C. (2004). Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol, 24( 7), 2875-89. eScholarID:1d9359 | DOI:10.1128/MCB.24.7.2875-2889.2004
2003
- Demonacos C, La Thangue NB. (2003). Drug discovery and p53 family. Progress in Cell Cycle Research. ( 5, pp. 375-382). eScholarID:3d755
- Demonacos C. (2003) Stress-responsive activator of P300 (STRAP) protein. eScholarID:13d38
2001
- Chan HM, Krstic-Demonacos M, Demonacos C, La Thangue NB. (2001). Acetylation control of the retinblastoma tumour-suppressor protein. Nature Cell Biology, 3, 667-673. eScholarID:1d7282 | DOI:10.1038/35083062
- Demonacos C, Krstic-Demonacos M, La Thangue NB. (2001). A TPR motif cofactor contributes to p300 Activity in the p53 response. Molecular Cell, 8, 71-84. eScholarID:1d7283 | DOI:10.1016/S1097-2765(01)00277-5