Dr Harmesh Aojula
Lecturer
- Email: harmesh.aojula@manchester.ac.uk
- Telephone: +44 (0)161 275 2874
Research
My research interest is focused on solid phase peptide chemistry and lipid vesicles .
Current projects in the following areas:
- Liposomes
- Therapeutic peptides
- Triggers for controlled drug release
- Cytolytic & Cell penetrating peptides
Teaching
Undergraduate modules
Pharmaceutical Analysis (Module Leader)
Medicinal chemistry
Pharmaceutical chemistry
Several courses connected with implementing Virtual Learning environment
Postgraduate research
Supervision of PhD and MPhil students in affilitaion with Prof David Clarke, Prof Ken Douglas, Prof David Attwood, Dr David Berk, Dr Alain Pluen, and Dr Jeff Penny.
Biography
Over 17 years experience in academia, commercial organisation & SMEs.
Qualifications
BSc, PhD Biological Chemistry (University of Essex)
Selected publications
2010
- Saleh, A.F., Aojula, H., Arthanari, Y., Offerman, S., Alkotaji, M., Pluen, A. (2010). Improved Tat-mediated plasmid DNA transfer by fusion to LK15 peptide. Journal of Controlled Release, 143(2), 233-242. eScholarID:84198 | DOI:10.1016/j.jconrel.2009.12.025
- Zheng, Z., Aojula, H., Clarke, D. (2010). Reduction of doxorubicin resistance in P-glycoprotein overexpressing cells by hybrid cell-penetrating and drug-binding peptide. Journal of Drug Targeting, 18(6), 477-487. eScholarID:84196 | DOI:10.3109/10611860903548347
2008
- PerryH.A.D, SalehA.F.A, Aojula H, Pluen A. (2008). YOYO as Dye to Track Penetration of LK15 DNA Complexes in spheroids: Use and Limits. Journal of Fluoresc, 1, 62-71. eScholarID:1d16520 | DOI:10.1007/s10895-007-0254-5
2007
- Saleh A.F. A, Aojula H, Pluen A. (2007). Enhancement of Gene Transfer using YIGSR analog of Tat-derived Peptide. Biopolymers, 10, eScholarID:1d16308
- SahehA.F.A, Aojula H, Pluen A. (2007). Improved Tat-mediated gent delivery in monolayer cell culture and multicellular tumour spheroids. Journal of Pharmacy & Pharmacology, Vol. 59, eScholarID:17d501
2006
- SalehA.A, Aojula H, Pluen A. (2006). Targeting improvement of Tat-derived pepticle based gene delivery using laminin receptor binding ligand (YIGSR). eScholarID:2d2351
- Aojula H, Barber J, Cullen RW, Andrews J. (2006). Computer-Based, online summative assessment in undergraduate pharmacy Teaching: The Manchester Experience. Pharmacy Education, 6, 229 - 236. eScholarID:1d13427
2002
- Aojula H, Offerman S, Aojula RajR, Hutchinson AlastairP, Nicklin S, Clarke DJ. (2002). Cloaking cytolytic peptides for liposome-based detection and potential drug delivery. BBA ( Biochimica et Biophysica Acta.), 1564, 73 - 81. eScholarID:1d1634 | DOI:10.1016/S0005-2736(02)00403-0
- Law BS, Offerman SC, Clarke DJ, Douglas KT, Aojula H. (2002). The Pyrene Excimer as a Probe of Peptide Tertiary Structure. Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries: Peptides, Proteins and Nucleic Acids-Small Molecule Organic Chemistry Diversity, 7th International Symposium, Southampton, UK, Sept 18-22, 2001, ed. Epton, R, publ. Mayflower, Kingswinford, England, 217-220. eScholarID:1d8778
2000
- Adetola B. Adesida, Raj R. Aojula, Aojula H, Clarke DJ. (2000). Nonepitopic antibody binding sequence: implications in screening and development of peptide vaccines. Vaccine, 18, 315-320. eScholarID:1d788